Type 1 Interferon Regulators as Prognostic Markers and Predictors of Therapeutic Response in Triple Negative Breast Cancer

Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer

DJ Zanker, AJ Spurling, NK Brockwell, KL Owen, JM Zakhour, T Robinson, HM Duivenvoorden, PJ Hertzog, SR Mullins, RW Wilkinson, BS Parker

2020-01-01

Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progressio..